REDUCTION OF IFOSFAMIDE TOXICITY USING DOSE FRACTIONATION

Google Scholar
  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (8) , 2945-2948
Abstract
Ifofamide was given in i.v. doses of 600-1200 mg/m2 per day for 5 days to 32 cancer patients, refractory to prior therapy, in an attempt to investigate the possibility of reducing toxicity by dose fractionation. Microscopic hematuria occurred in 14% and gross hematuria in only 10% of the patient trials. Azotemia did not occur in any patient on this study. Reversible myelosuppression was comparable to that found by other investigators. Other side effects such as nausea and mental confusion occurred infrequently. Ifosfamide produced antitumor effect in 7 of 27 evaluable patients. Renal and bladder toxicity of ifosfamide can be substantially reduced if the drug is administered in i.v. infusions of 1-2 h daily for 5 days.

This publication has 2 references indexed in Scilit: