Clinical implications of E-cadherin associated hereditary diffuse gastric cancer
Open Access
- 1 June 2004
- Vol. 53 (6) , 775-778
- https://doi.org/10.1136/gut.2003.022061
Abstract
Approximately 1–3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).Keywords
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