Studies on Chick-Embryo-Adapted-Rabies Virus

Open Access
Publisher Website
Google Scholar
Abstract
Summary: After prolonged cultivation in the developing chick embryo the Flury strain of rabies virus lost its pathogenic properties for mice 14 days of age or older when injected intracerebrally. Suckling mice still remained fully susceptible. Dogs and rabbits were fully resistant to intracerebral inoculation of the virus, whereas rhesus monkeys were found to be almost as susceptible as baby mice. Results of titrations of the virus in hamsters and guinea-pigs indicated the virus preparation was not homogeneous. Experiments are described in which different segments of the viral population were separated and analyzed. The existence of different forms of virus in different stages of adaptation is discussed.

This publication has 0 references indexed in Scilit: