Mitral valve prolapse, aortic compliance, and skin collagen in joint hypermobility syndrome.
Open Access
- 1 November 1985
- Vol. 54 (5) , 501-508
- https://doi.org/10.1136/hrt.54.5.501
Abstract
Mitral valve prolapse was sought clinically and with phonocardiography and M mode and sector echocardiography in 15 women aged 22-57 years with joint hypermobility syndrome. The type III:III + I collagen ratio was measured in skin biopsy specimens and was found to be raised in seven of 10 patients sampled. Thirteen patients had increased aortic wall compliance measured by the continuous wave Doppler ultrasound technique. Ten (67%) patients had mitral valve prolapse shown by auscultatory signs or echocardiography or both--a prevalence at least three times greater than that in the general adult population. It is concluded that if the abnormality of collagen biosynthesis found in skin biopsy samples in these patients is also present in their mitral valve tissue this may predispose them to prolapse of the valve.This publication has 37 references indexed in Scilit:
- Mitral valve prolapse and bacterial endocarditis: When is antibiotic prophylaxis necessary?American Heart Journal, 1985
- Sudden death in primary mitral valve prolapseAmerican Heart Journal, 1984
- Mitral valve prolapse: a consistent manifestation of type IV Ehlers-Danlos syndrome. The pathogenetic role of the abnormal production of type III collagen.Circulation, 1981
- Clinical spectrum and long-term follow-up of isolated mitral valve prolapse in 119 children.Circulation, 1980
- Mild mitral regurgitation and the mitral prolapse fiascoAmerican Heart Journal, 1980
- Mitral valve prolapse in one hundred presumably healthy young females.Circulation, 1976
- The problem of nonejection systolic clicks and associated mitral systolic murmurs: Emphasis on the billowing mitral leaflet syndromeAmerican Heart Journal, 1975
- Aortic root dilatation and mitral valve prolapse in Marfan's syndrome: an ECHOCARDIOgraphic study.Circulation, 1975
- The Variable Spectrum of Echocardiographic Manifestations of the Mitral Valve Prolapse SyndromeCirculation, 1974
- Chordae tendineae rupture complicating the systolic click-late systolic murmur syndromeThe American Journal of Cardiology, 1974