No Effect of Low-dose 1α-Hydroxycholecalciferol Treatment on the Renal Function Deterioration Rate in Long-term Uraemic Rabbits

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Abstract
The development of renal function during 18 wk of oral treatment with 1.alpha.-hydroxycholecalciferol was investigated in rabbits with surgically induced chronic renal failure. Renal function was evaluated by the serum creatinine concentration and the 51Cr-EDTA clearance measured by the single injection technique. Three groups of uremic rabbits on 3 different diets with high, medium and low content of Ca and phosphate were studied. The treatment with 0.02 .mu.g/kg per day of 1.alpha.-hydroxycholecalciferol did not induce statistically significant changes in the serum concentrations of Ca or phosphate. Compared to placebo 1.alpha.-hydroxycholecalciferol did not increase the deterioration rate of renal function in any of the 3 groups.