TRANS-PLACENTAL TRANSFER OF 4 ANTI-INFLAMMATORY AGENTS - A STUDY CARRIED OUT BY INVITRO PERFUSION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 10  (1) , 7-11
Abstract
Placental transfer (TFp) of phenylbutazone [PB], oxyphenylbutazone [OPB], ketoprofen [KPF] and indocid [indomethacin, IM] was studied by perfusing a placental cotyledon at term in vitro. These drugs were used in the therapeutic doses employed in human clinical practice. Antipyrine was used as a control material to check the validity of the perfusion in each experiment. TFp of PB was 25.83 .+-. 0.46%, of OPB 22.48 .+-. 1.38% of KPF 35.574 .+-. 0.95% and of IM 36.19 .+-. 0.26%. The advantages and the possible dangers of nonsteroid anti-flammatory agents used in pregnant women are discussed. The use of KPF over IM is suggested because the anti-prostaglandin properties of KPF are greater, although the TFp is significantly less.

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