Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains
- 1 May 1994
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 7 (1) , 54-58
- https://doi.org/10.1038/ng0594-54
Abstract
Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.Keywords
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