Irreversible binding of pristinamycin IIA (streptogramin A) to ribosomes explains its "lasting damage" effect.
- 1 January 1986
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 39 (9) , 1322-1328
- https://doi.org/10.7164/antibiotics.39.1322
Abstract
In vitro and in vivo studies are presented to test the hypothesis that the synergistic action of the pristinamycins is not due to a catalytic effect of prostinamycin IIA (PIIA) on the bacterial ribosome. We demonstrate that there is a proportionality between the quantity of PIIA bound on the ribosome and pristinamycin IA (PIA) retained by it. Moreover in vitro and in vivo experiments correlated to biological effects (growth and protein synthesis) demonstrate that pristinamycin IIA is tightly bound on 70S ribosome, which satisfactory explains the so called "lasting damage effect".This publication has 3 references indexed in Scilit:
- Lasting damage to bacterial ribosomes by reversibly bound virginiamycin M.Proceedings of the National Academy of Sciences, 1980
- A spectrofluorimetric study of the interaction between virginiamycin S and bacterial ribosomesMolecular Genetics and Genomics, 1978
- METHODES DE DOSAGE DES CONSTITUANTS DE LA PRISTINAMYCINE DANS LES LIQUIDES BIOLOGIQUES1965