Tumorigenicity and Antigenicity of Mouse Cells Infected With Simian Virus 40. I. Relationship of Growth In Vitro and In Vivo in Immunosuppressed and Immunocompetent Recipients2
- 1 September 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 51 (3) , 951-959
- https://doi.org/10.1093/jnci/51.3.951
Abstract
The relationship between tumorigenicity and antigenicity of transformed cells in culture was examined. BALB/3T3 and several different classes of simian virus 40 (SV40) transformants derived from BALB/3T3 were tested for their ability to produce tumors in immunosuppressed recipients and to induce specific transplantation resistance to a transplantable SV40 tumor in immunocompetent recipients. SV40 tumors were defined by expression of the SV40 tumor (T) antigen and the SV40 tumor-specific transplantation (TST) antigen. Only SV40-transformed cell lines expressing the TST antigen caused SV40 tumors. Although the “flat” transformants contained the T antigen in culture, they produced no SV40 tumors. Some cell lines lacking the SV40 TST antigen were tumorigenic, but the tumors were not SV40 derived. The SV40 TST antigen appeared to represent a unique marker for cells with the potential to become SV40 tumors.Keywords
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