Late effects following isoniazid therapy.
- 1 September 1980
- journal article
- research article
- Published by American Public Health Association in American Journal of Public Health
- Vol. 70 (9) , 987-989
- https://doi.org/10.2105/ajph.70.9.987
Abstract
Amont 338 women treated in Massachusetts with isoniazid (isonicotinic acid hydrazide = INH) for pulmonary tuberculosis, no excess cancer deaths occurred (8 observed vs 8.3 expected) after 23 years (12.9 mean) of follow-up. There was an excess of cancer deaths (54 vs 35.7) among 1,090 patients who did not receive INH, partly due to radiogenic breast cancer resulting from multiple chest fluoroscopies to monitor pneumothorax. Increased deaths from liver cirrhosis (5 vs 0.8) were observed following INH use, suggesting that chronic as well as acute liver disease complicate this treatment.This publication has 30 references indexed in Scilit:
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