Studies on Thermostable Antigens Extracted from Bacterium Tularense and from Tissues of Animals Dead of Tularemia

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Abstract
Summary: Thermostable antigens may be extracted from suspensions of Bacterium tularense or from tissues of animals succumbing to infections with this organism. These react specifically with antitularense serum and cause production of specific agglutinins and precipitins when inoculated intravenously into rabbits. They are insoluble in 50 per cent acetone at a pH of 5.2 or lower. Thermostable antigens persist in tissues obtained from animals dead of tularemia and maintained at a temperature of 37 C for 14 days. The application of thermoprecipitin tests to clinical and epidemiological problems is discussed.

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