Dynamics of the Interaction between Entamoeba histolytica and Components of the Immune Response

Publisher Website
Google Scholar
Abstract
The possible implications of cell membrane dynamics in the host parasite relationship has been studied. Entamoeba histolytica rapidly redistributed and internalized antibodies and Con A bound to its surface. The process was dependent on temperature, cell metabolism and changes of pH in the environment. Phagocytizing amoebae displayed a higher rate of membrane perturbations, which were similarly affected by temperature, cell metabolism and pH variations. Cytochalasin B partially inhibited the redistribution whereas colchicine did not. Colchicine in combination with Cytochalasin B augmented the inhibitory effect of Cytochalasin B alone. The expression of antigens as the surface of the amoeba showed cyclic fluctuations during cell growth.