Epidermal growth factor receptors in human breast cancer
- 1 September 1984
- journal article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 4 (3) , 189-193
- https://doi.org/10.1007/bf01806484
Abstract
The capacity for specific binding of125I-epidermal growth factor (EGF) was studied in crude membrane fractions from 95 human breast carcinomas. About 42% of the samples showed saturable, high affinity, specific binding of EGF. In 21% of the tumors we were able to demostrate high (above 10 fmoles/mg protein) binding capacity. Moreover, high EGF receptor values were associated with a low content of estradiol receptor. These studies are related to the definition of new biochemical markers in human breast cancer.Keywords
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