Synthesis and properties of γ-hydroxyarginine
- 1 August 1968
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 46 (8) , 725-729
- https://doi.org/10.1139/o68-111
Abstract
Gamma-Hydroxyargi-nine was prepared by 2 methods. In method I, the product of reaction between epichlorohydrin and ethyl sodiomalonate was treated with concentrated NH4OH. Then successively, reaction products were treated with O-methylisourea hydrogen sulfate at pH 11.5, Br, concentrated NH4OH, and trypsin at pH 9.0. In method II, it was prepared by the direct guanidination of gamma-hydroxyomithine. The product was homogeneous as indicated by column chromatography and paper electrophoresis. It was converted to arginine upon reductions with HI and red P, and to gamma-hydroxyomithine upon deguanidation by treatment with Ba(OH)2.This publication has 2 references indexed in Scilit:
- Pseudomonas Cytochrome c. I. Effect of Modification of the Amino Groups*Biochemistry, 1967
- The Mode of Action of the Crystalline Pancreatic Proteolytic Enzymes.Chemical Reviews, 1950