ERYTHROCYTE AGE AND CHOLINESTERASE ACTIVITY

Abstract
Repeated hemorrhage in rats produces progressive increases in erythrocyte cholinesterase activity. Upon cessation of hemorrhage the cholinesterase activity declines to normal levels. When centrifuged, rat erythrocytes distribute so that younger red cells are found in the upper part of the centrifugate. These red cells possess much higher cholinesterase activities than erythrocytes found in the lower regions of the packed cells. A possible mechanism explaining the variations of erythrocyte cholinesterase activity in anemias is offered.

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