Choriocarcinoma in Mother and Child, Identified by Immunoenzyme Histochemistry
Open Access
- 1 March 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 67 (3) , 279-283
- https://doi.org/10.1093/ajcp/67.3.279
Abstract
Nieuwenhuijzen Kruseman, Arie C, van Lent, Mat, Blom, Anneke H., and Lauw, G. Pam: Choriocarcinoma in mother and child, identified by immunoenzyme histochemistry. Am J Clin Pathol 67: 279–283, 1977. A case of metastatic choriocarcinoma after term pregnancy, with tumor localization in the kidney of a hydropic stillborn infant, is presented. The primary tumor was found in a scraping four weeks after delivery. The identity and nature of the malignant growth in mother and child were substantiated by identical immunohistochemical patterns for gonadotropin activity. Because of a positive Kleihauer test it was assumed that massive fetomaternal transfusion had caused the hydrops and intrauterine death. Now, four and a half months after starting methotrexate therapy, the mother seems to be free of tumor. Plasma human chorionic gonadotropin titers have decreased to normal.Keywords
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