Disruption of White Matter Integrity in the Inferior Longitudinal Fasciculus in Adolescents With Schizophrenia as Revealed by Fiber Tractography

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Abstract
Adolescents with early-onset schizophrenia (EOS) (defined as onset of psychotic symptoms by age 18 years) provide a unique opportunity to examine regional and disease-specific late abnormal brain development in schizophrenia.1 Prior anatomical brain magnetic resonance imaging (MRI) studies conducted in EOS have revealed a striking postpsychotic progressive loss of cortical gray matter during adolescence, which could either reflect abnormalities in synaptic pruning or an increase in myelinated white matter.2