Linkage between X‐chromosome markers and manic‐depressive illness
- 1 September 1984
- journal article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 70 (3) , 282-287
- https://doi.org/10.1111/j.1600-0447.1984.tb01210.x
Abstract
Pedigrees of manic-depressive patients in treatment at the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan-deutan-glucose-6-phosphate-dehydrogenase region of the X-chromosome. Two informative pedigrees were found, investigated and analyzed for linkage using a multigenerational model and considering age-dependent penetrance. The results are consistent with the hypothesis of X-linkage in major affective illness.Keywords
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