Coenzyme A Activity in Tissues of Normal and Scorbutic Guinea Pigs

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Abstract
Acute scurvy was produced in guinea pigs by paired feeding technique. Urinary excretion of injected P-aminobenzoic acid (PABA) in the acetylated form was estimated in scorbutic and paired fed normal guinea pigs. Scorbutic animals excreted decreased amounts of acetylated PABA. Co A activity of liver, kidney and brain of scorbutic and paired fed normal guinea pigs was determined. Co A activity which was present in the tissues of normal guinea pigs did not change during scurvy. Total body cholesterol of scorbutic guinea pigs increased significantly. Implications of the results obtained were discussed.