Conventional and Microbeam Studies Using Low Energy Charged Particles Relevant to Risk Assessment and the Mechanisms of Radiation Action

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Abstract
A study of the effectiveness of low energy charged particles has shown that in the LET range 20-38 keV.µm-1, protons and deuterons are more effective than a particles of equivalent LET. These differences may reflect dissimilarities in the track structures and have important consequences both for mechanistic studies and risk assessment. This work will underpin investigations into mechanisms of radiation action and extreme low dose responses using a charged particle microbeam. This facility will enable cells to be irradiated individually using singly and doubly charged particles. Using this approach it is possible to devise in vitro models that are a more realistic representation of the situation relevant to environmental exposures to charged particles where single particle effects predominate. With sufficient spatial resolution (at present 5µm, but with (1 µm in prospect) the microbeam will also be useful in addressing observations related to cellular spatial sensitivity, for example the identification of critical sub-cellular targets.

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