50-FOOT WALKING TIME: A CRITICAL ASSESSMENT OF AN OUTCOME MEASURE IN CLINICAL THERAPEUTIC TRIALS OF ANTIRHEUMATIC DRUGS
- 1 October 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Rheumatology
- Vol. 27 (5) , 372-374
- https://doi.org/10.1093/rheumatology/27.5.372
Abstract
Fifty-foot walking time was used in 51 of 187 clinical therapeutic trials of antirheumatic drugs and in only 21 instances was statistical significance reached. Measurement of the 50-foot walking time showed no better performance in long-term trials of SAARDs than in short-term trials of NSAIDs. It is concluded that the 50-foot walking time is a poor outcome measure in rheumatic disease trials, despite a high intra- and inter- observer reproducibility.Keywords
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