Non-Specific Reversal by Vitamins of Inhibition of Ethanol Oxidation by Antabuse (Tetraethylthiuramdisulfide) in the Rat

1 February 1954

journal article
research article
Published by Frontiers Media SA in Experimental Biology and Medicine

Vol. 85 (2) , 252-254
https://doi.org/10.3181/00379727-85-20846

Abstract

The inhibition of alcohol oxidation by tetraethyl-thiuramisulfide was reversed by the simultaneous admn. of large doses (20 nag.) of the vitamins, nicotinamide, pyridoxine, riboflavin, thiamine, folic acid, and ascorbic acid. The toxicity of alcohol to antabuse-treated animals was not counteracted by the delayed admn. of nicotinamide.

Keywords

ALCOHOL, ETHYL/METABOLISM
DISULFIRAM/EFFECTS
OXIDATION-REDUCTION
VITAMINS/EFFECTS

This publication has 1 reference indexed in Scilit:

Is acetaldehyde an intermediary product in normal metabolism?
Biochimica et Biophysica Acta, 1950