Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2
- 18 July 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (20) , 4259-4264
- https://doi.org/10.1016/j.febslet.2005.06.057
Abstract
Macrophages undergo apoptosis as a mechanism of regulating their activation and the inflammatory reaction. Macrophages express the Corticotropin‐Releasing Factor Receptor‐2 (CRFR2) the endogenous agonists of which, the urocortins, are also present at the site of inflammation. We have found that urocortins induced macrophage apoptosis in a dose‐ and time‐dependent manner via CRFR2. In contrast to lipopolysaccharide (LPS)‐induced apoptosis, the pro‐apoptosis pathway activated by urocortins involved the pro‐apoptotic Bax and Bad proteins and not nitric oxide, JNK and p38MAPK characteristic of LPS. In conclusion, our data suggest that endogenous CRFR2 ligands exert an anti‐inflammatory effect via induction of macrophage apoptosis.Keywords
This publication has 26 references indexed in Scilit:
- Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivityNeuropharmacology, 2004
- Corticotropin-Releasing Hormone Augments Proinflammatory Cytokine Production from Macrophages In Vitro and in Lipopolysaccharide-Induced Endotoxin Shock in MiceInfection and Immunity, 2002
- Aurintricarboxylic Acid Protects against Cell Death Caused by Lipopolysaccharide in Macrophages by Decreasing Inducible Nitric-Oxide Synthase Induction via IκB Kinase, Extracellular Signal-Regulated Kinase, and p38 Mitogen-Activated Protein Kinase InhibitionMolecular Pharmacology, 2002
- Corticotropin-releasing Hormone Induces Fas Ligand Production and Apoptosis in PC12 Cells via Activation of p38 Mitogen-activated Protein KinasePublished by Elsevier ,2002
- Urocortin Messenger Ribonucleic Acid: Tissue Distribution in the Rat and Regulation in Thymus by Lipopolysaccharide and GlucocorticoidsEndocrinology, 1999
- Urocortin and Inflammation: Confounding Effects of Hypotension on Measures of InflammationNeuroimmunomodulation, 1999
- Differential Induction of Apoptosis by Fas–Fas Ligand Interactions in Human Monocytes and MacrophagesThe Journal of Experimental Medicine, 1997
- Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factorNature, 1995
- Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis.Gut, 1995