The Surgical Pathology of Malformations in the Kidneys and Ureters

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Abstract
Inherited protoplasmic insufficiency is specifically expressed by incomplete or delayed differentiation in nephrons and their surrounding stroma. The histological diagnosis is made by recognizing mesenchymal stroma in which nephron units are in different stages of delayed differentiation. The subcapsular zone gives the earliest evidence of both developmental delay and cystic degeneration in kidneys, liver, or other organs. Growth impulse, differentiation, and cystic degeneration are not identically timed in both kidneys or in the different parts of organs involved.