Mycobacterium ulceransCytotoxicity in an Adipose Cell Model
Open Access
- 1 November 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (11) , 7182-7186
- https://doi.org/10.1128/iai.69.11.7182-7186.2001
Abstract
An adipose cell (SW872) model was developed to observe cellular necrosis and apoptosis upon Mycobacterium ulceransinfection and treatment with mycobacterial exudate. Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors inM. ulcerans may be involved in Buruli ulcer pathogenesis.Keywords
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