Re-Evaluation of Myocardial Blood Flow With Modified Radioisotope Technique

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Abstract
A modified radioisotope technique was used in a double-blind study in angina patients to estimate myocardial blood flow and cardiac output after the administration of a placebo, 2 dosage forms of pentaerythritol tetranitrate (PETN), and various amounts of alcoholic beverages. Both 20 mg tablets (PETN) and 80 mg sustained action tablets (SA) produced increases in mean myocardial blood flow at 2 and 4 hours after the last dose. The SA form increased myocardial blood flow for periods up to 10 hours. Neither regimen caused changes in mean cardiac output that were statistically significant from control values. The results following administration of alcohol show considerable variability in onset of action and a tendency to decrease myocardial blood flow, suggesting that alcohol does not produce a consistent effect on the coronary circulation.