Cytogenetic investigations on mice treated with lead
- 1 January 1977
- journal article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 2 (3) , 619-624
- https://doi.org/10.1080/15287397709529462
Abstract
Dietary lead at different dose levels was given to female C57B1 mice for periods up to 3 months. No severe chromosome or chromatid aberrations were observed at any dose level and the frequency of chromatid gaps increased significantly only at the highest doses. (0.5 and 1% of lead in the diet). The number of micronuclei in polychromatic erythrocytes also remained at control levels after lead treatment, whereas known mutagenic agent such as Myleran and Mitomycine C raised their incidence markedly. Taking into account also the data in the literature, it is concluded that lead per se probably has no mutagenic action on mammals.Keywords
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