Use of an NK1 Receptor Antagonist to Prevent Delayed Emesis After Cisplatin
Open Access
- 4 June 1997
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 89 (11) , 817-818
- https://doi.org/10.1093/jnci/89.11.817
Abstract
Despite the use of serotonin antagonists, most patients continue to experience vomiting with chemotherapy, particularly delayed emesis. Substance P, a regulatory peptide (1), induces vomiting (2) and binds to the NK1 neuroreceptor. Compounds that block the NK1 receptor (3–6) lessen emesis after cisplatin, ipecac, copper sulfate, apomorphine, and radiation therapy (4,5). This broad activity suggests that substance P and the receptor may play central roles in emesis. We evaluated the NK1 receptor antagonist CP-122,721 in 17 cancer patients receiving cisplatin (⩾80 mg/m2 over 7) and delayed vomiting in 89% (8). CP-122,721 (1 mg/kg) prevented emesis after cisplatin in the ferret model that predicted the activity and dose of serotonin antagonists (9,10).Keywords
This publication has 10 references indexed in Scilit:
- Are more antiemetic trials with a placebo necessary? Report of patient data from randomized trials of placebo antiemetics with cisplatinCancer, 1996
- Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferretsEuropean Journal of Pharmacology, 1996
- Optimum anti-emetic therapy for cisplatin induced emesis over repeat courses: Ondansetron plus dexamethasone compared with metoclopramide, dexamethasone plus lorazepamAnnals of Oncology, 1996
- The pharmacology of GR203040, a novel, potent and selective non‐peptide tachykinin NK1 receptor antagonistBritish Journal of Pharmacology, 1995
- The anti‐emetic effects of CP‐99,994 in the ferret and the dog: role of the NK1 receptorBritish Journal of Pharmacology, 1995
- Behavioral studies of emetic sensitivity in the ferretBrain Research Bulletin, 1993
- Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferretsEuropean Journal of Pharmacology, 1993
- A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) ReceptorScience, 1991
- Controlling delayed vomiting: double-blind, randomized trial comparing placebo, dexamethasone alone, and metoclopramide plus dexamethasone in patients receiving cisplatin.Journal of Clinical Oncology, 1989