IODINE CONTAINING SUBCELLULAR PARTICLES IN THYROID TISSUE1

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Abstract
Iodine-containing subcellular particles in homogenates of a transplantable thyroid tumor in rats have been shown to be heterogeneous with respect to density and size. Three more or less distinct groups of such particles have been isolated on the basis of particle size. Two of these would be isolated with the “mitochondrial” fraction and one with the “microsomal” fraction by classical techniques. Similar groups of iodine containing particles have been found in nontumorous thyroid tissue from various animals. The distribution of iodine in the particles of hog thyroid is similar to the distribution in the tumor particles. The two groups of smaller iodine containing particles in hog thyroid tissue correspond closely with particles from this tissue which produce a participate iodoprotein in a cell-free system. No role in hormone biosynthesis can yet be assigned to these particles.

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