Experimental chronic dermatophilosis

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Abstract
The effect of artificially induced climatic changes or arthropod bites on the development of experimental dermatophilosis lesions was examined. The lesions were produced following application of Dermatophilus congolensis zoospores to the skin of goats.When zoospores were applied to skin which had been treated with methanol, the resulting lesion healed rapidly. This observation contrasts with the disease under natural conditions, where lesions become chronic. There was no increase in the time for lesions to heal if the goats were sprayed with water to simulate rainfall. However, if a delayed hypersensitivity reaction to chlorodinitrobenzene was induced at the site of zoospore application (to simulate the host's response to an arthropod bite), the resulting lesion was morphologically similar to natural lesions and failed to heal so long as applications of the chemical were repeated.It is suggested that arthropods play a primary role in producing chronic lesions by inducing an immune reaction at the site of infection with D. congolensis.

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