Urinary antibody response after immunisation with a vaccine against urinary tract infection

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Abstract
Immunisation of mice with SolcoUrovac® vaccine induced an approximately 10-fold increase of the total amount of IgG and a 2-fold increase of IgA immunoglobulins in urine. IgG antibodies to Solco-Urovac antigens appeared in urine after the first injection, and booster injections caused a further increase of the titer. IgA antibodies appeared in the urine after the second injection, and the third injection doubled the titer. IgM immunoglobulins and specific IgM class antibodies to Solco Urovac were not found in any urine tested. The exact origin of the immunoglobulins in the urine as well as the spcificity of immune response is discussed.