Design, Synthesis, and Evaluation of a Radicicol and Geldanamycin Chimera, Radamide
- 30 October 2004
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 6 (24) , 4459-4462
- https://doi.org/10.1021/ol048266o
Abstract
A chimera composed of the natural products radicicol and geldanamycin has been prepared through an amide linkage connecting the resorcinol moiety of radicicol to the quinone ring of geldanamycin. The inhibitory activity of these compounds was determined by their ability to inhibit Hsp90's inherent ATPase activity along with degradation of the Hsp90 client protein, HER-2 in MCF-7 breast cancer cells. [reaction: see text]Keywords
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