Lymphocyte Classes in New Zealand Mice

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Abstract
Newborn through 1-year-old NZB mice demonstrate a 30 to 50% decrease in the frequency of κ-bearing splenic lymphocytes, compared to similarly aged BALB/c mice. In addition, the frequency of immunoglobulin-bearing cells among lymph node and spleen cell populations of 6-week-old NZB, NZW and (NZB × NZW)F1 mice is substantially decreased compared to five normal strains. In NZ animals, the immunoglobulin-bearing cells appear to be replaced by a nonthymus-derived lymphocyte which lacks detectable ϑ or κ chain determinants. Although the significance of these cells is yet uncertain, they may be an early manifestation of a basic immunologic defect in NZ animals.

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