THE DISTRIBUTION OF FERROCYANIDE, INULIN, CREATININE AND UREA IN THE BLOOD AND ITS EFFECT ON THE SIGNIFICANCE OF THEIR EXTRACTION PERCENTAGES

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Abstract
Na ferrocyanide and inulin injected intraven. into a dog circulate in the plasma without entering the erythrocytes in measurable amounts. Creatinine absorbed or injected into the circulation gradually enters the blood cells. However, diffusion between cells and plasma is so slow, that, when the blood perfuses the kidneys, where plasma creatinine concn. falls 20%, the fall in cell creatinine is too slight to measure. Urea diffuses so quickly that when added to blood it reaches equilibrium between cells and plasma before they can be separated for analysis. The rapid diffusibility also causes the observed % fall in urea concn. from arterial to renal venous blood to be the same in cells as in plasma. The effects of these diffusibility differences on the relative concn. decreases of these substances in plasma and in whole blood during perfusion of the kidneys have been calculated. From comparison of the mean plasma extraction % of urea with that of the presumably non-reabsorbed substances, ferrocyanide, inulin and creatinine, it is calculated that in the dog an average of 38% of the filtered urea is reabsorbed. This figure agrees reasonably well with the value, 43%, obtained in the preceding paper from comparison of clearances.

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