The master control gene for morphogenesis and evolution of the eye
- 1 January 1996
- journal article
- review article
- Published by Wiley in Genes to Cells
- Vol. 1 (1) , 11-15
- https://doi.org/10.1046/j.1365-2443.1996.11011.x
Abstract
The human Aniridia, the murine Small eye, and the eyeless mutations of Drosophila affect homologous (Pax‐6) genes that contain both a paired‐ and a homeobox. By ectopic expression of these genes, functional eyes can be induced on the legs, wings, and antennae of the fly, indicating that eyeless (Pax‐6) is the master control gene for eye morphogenesis. The finding of Pax‐6 from flatworms to humans suggests that eyeless is a universal master control gene and that the various types of eyes in the various animal phyla may have evolved from a single prototype.Keywords
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