Carbohydrate Metabolism in Brain Disease

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Abstract
Two earlier studies from this laboratory showed that abnormally large amounts of lactic acid accumulate in the blood after administration of glucose1or fructose2in many patients with schizophrenic or manicdepressive psychoses. Another study3showed that administration of corticotropin (ACTH) or hydrocortisone to psychotic patients who did not have this abnormality regularly produced it. Other observers had previously demonstrated a disturbance of lactate metabolism during exercise in these psychoses.* In view of these findings, it was decided to study the effects of intravenously infused sodiumd-lactate in normal and psychotic subjects. Materials and Methods Ten grams ofd-lactate, in the form of the sodium salt, was dissolved in 500 ml. of isotonic salt solution and given intravenously in 30 minutes. Blood samples were taken before and at the end of the infusion and again 15 and 30 minutes later. The methods used were as previously

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