T-Lymphocyte Subsets in Cerebrospinal Fluid in Multiple Sclerosis

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Abstract
To the Editor: Alterations in subpopulations of T lymphocytes appear to be important in the pathogenesis of multiple sclerosis. In particular, suppressor T cells in peripheral blood fluctuate with the clinical stage of disease when measured either by rosetting techniques1 or by fluorescence staining with monoclonal antibodies.2 Although immunologic changes within the central nervous system may be more accurately reflected in cerebrospinal-fluid lymphocytes than in peripheral-blood lymphocytes, little information on subsets of T cells in cerebrospinal fluid is available. In normal cerebrospinal fluid, there is an increase in total T (E-rosette-forming) cells and a decrease in B cells.3 With similar . . .