Preparation of useful chiral lactone synthons via stereospecific enzyme-catalysed oxidations of meso-diols
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 11,p. 515-516
- https://doi.org/10.1039/c39800000515
Abstract
Horse liver alcohol dehydrogenase-catalysed oxidations of symmetrical acyclic and cyclic meso-diol substrates give chiral γ- and δ-lactones in high yields and of 100% enantiomeric excess and provide access to a broad range of useful synthons of value in asymmetric syntheses of natural products.Keywords
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