Studies with Brugia pahangi 17. The Anthelmintic Effects of Diethylcarbamazine

Publisher Website
Google Scholar
Abstract
Diethylcarbamazine (DEC) was active in vitro against infective larvae and microfilariae of B. pahangi but only at high concentrations. When fed to mosquitoes which were infected with B. pahangi it had little or no activity. In jirds it was inactive against B. pahangi microfilariae and adults when administered at 300 mg/kg for 5 days by the i.p. or oral route. In cats given 25 or 50 mg DEC/kg i.p. on 3 or 5 occasions it was not microfilaricidal, but most of the adult worms died within 30 days of the end of treatment. Although most microfilariae disappeared from the blood of cats immediately (i.e., within 1 h) after treatment, they reappeared within a few hours in the same numbers. Microfilarial levels were reduced after treatment but there was no precipitate decline as occurs in human B. malayi patients.