The Identification of Local Anæsthetic Drugs of the Benzoic Ester Group

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Abstract
Summary: A scheme is described for the characterisation and identification of the eleven local anæsthetic drugs of the benzoic ester group at present commercially available in this country. The complete scheme is designed in five distinct stages, any of which may be omitted if identification is otherwise satisfactorily achieved: (i) purification of the crude material by precipitation of the hydrochloride from an ethereal solution of the base; (ii) reactions with the common alkaloidal reagents; (iii) demonstration of the presence of the benzoic ester structure; (iv) simple crystal tests and colour reactions with the three reagents, potassium iodide, potassium permanganate and potassium dichromate. (v) final identification by micro-mixed melting-point determination.

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