Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.
- 1 August 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (8) , 4489-4493
- https://doi.org/10.1073/pnas.77.8.4489
Abstract
An octacosapeptide named pro-somatostatin was isolated from acid extracts of procine hypothalami and had the amino acid sequence .**GRAPHIC**. This octacosapeptide possesses high somatotropin (growth hormone) and prolactin release-inhibiting activity in vitro. It also crossreacts strongly with antisera generated against the somatostain tetradecapeptide. This octacosapeptide is most likely a precursor (pro-hormone) of somatostatin in the hypothalamus. The existence of still larger molecular size precursors of somatostatin was observed.This publication has 32 references indexed in Scilit:
- New Protein Sequenator with Increased SensitivityScience, 1980
- N‐terminally extended somatostatin: The primary structure of somatostatin‐28FEBS Letters, 1980
- Immunological and biochemical characterization of distinct high molecular weight forms of neurophysin and somatostatin in mouse hypothalamus extractsFEBS Letters, 1979
- Isolation of a porcine intestinal peptide with C-terminal somatostatinBiochemical and Biophysical Research Communications, 1978
- Multiple forms of somatostatin‐like immunoreactivity in canine pancreasFEBS Letters, 1978
- Direct microsequence analysis of polypeptides using an improved sequenator, a nonprotein carrier (Polybrene), and high pressure liquid chromatographyBiochemistry, 1978
- Polypeptide secondary structure may direct the specificity of prohormone conversionFEBS Letters, 1978
- Abnormal Behaviour of Proline in the Isothiocyanate DegradationHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1976
- Somatostatin: Abundance of Immunoreactive Hormone in Rat Stomach and PancreasScience, 1975
- Influence of Previous Cooling of Rat Pituitaries on the Release of GH, LH and Prolactin in vitroNeuroendocrinology, 1973