Effect of Hyperthermia on Experimental Bladder Tumors
- 1 January 1981
- journal article
- research article
- Published by Elsevier in European Urology
- Vol. 7 (2) , 100-104
- https://doi.org/10.1159/000473190
Abstract
Studies were made on hyperthermic treatment of BC-50 bladder cancer cells in ACI/N rats with the following results: (1) Hyperthermia had a marked cytotoxic effect on BC-50 transitional carcinoma cells in vitro. (2) In vivo, heat treatment for 30 min was insufficient, but heat treatment for 60 min or more was effective. (3) A significant difference was found between the effects of heat treatment at 41 and 42 °C, indicating that the critical temperature for killing tumor cells was 42 °C. (4) BC-50 tumor itself was sensitive to the X-ray irradiation so that we could not evaluate the effect of combination treatment of hyperthermia and X-ray irradiation. (5) Hyperthermia in combination with X-ray irradiation prolonged the survival rate of the rats.Keywords
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