.BETA.-Hydroxy-.DELTA.-lactones as chiral building blocks involving 1,3-dihydroxyl functions. 1. New strategies for stereoselective construction of 2-methyl-3,5-dihydroxy esters.
- 1 January 1990
- journal article
- letter
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (10) , 2890-2892
- https://doi.org/10.1248/cpb.38.2890
Abstract
Four possible isomers of 2-methyl-3,5-dihydroxy ester derivatives, useful building blocks for natural product synthesis, were synthesized stereoselectivity using C3-hydroxyl-directed methylation of .beta.-hydroxy-.delta.-lactone and .beta.,.delta.-dihydroxy ester.This publication has 3 references indexed in Scilit:
- Microbial products. 9. Roxaticin, a new oxo pentaene antibioticThe Journal of Organic Chemistry, 1989
- Polyhydroxylated seven-membered chiral building blocks. Asymmetric synthesis of compactin analogsThe Journal of Organic Chemistry, 1989
- Scytophycins, cytotoxic and antimycotic agents from the cyanophyte Scytonema pseudohofmanniThe Journal of Organic Chemistry, 1986