Solution-phase synthesis of .ALPHA.-human atrial natriuretic peptide (.ALPHA.-hANP).

1 January 1990

journal article
research article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 38 (2) , 382-388
https://doi.org/10.1248/cpb.38.382

Abstract

.alpha.-Human atrial natriuretic peptide (.alpha.-hANP) was synthesized by assembling six peptide fragments in solution followed by deprotection with HF and subsequent air-oxidation. The trimethylbenzyl group was employed as an S-protecting group of cysteine. The HF-dimethylselenide-m-cresol system was employed as a final deprotecting reagent and, at the same time, as a reducing reagent of Met(O). Synthetic .alpha.-hANP elicited potent diuretic and natriuretic activity in rats.

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