PRE-PINPOINT PAPULES CHANGES PRECEDING PIN-POINT LESIONS OF PSORIASIS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 59  (85) , 39-45
Abstract
Skin areas of 10 .times. 10 cm were marked out and closely observed during 14 days in 22 patients with active and 18 cases with less active psoriasis. The 1st changes, minute papules, slightly erythematous, almost flush with the skin (pre-pinpoint papules), appeared within this period and transformed after several days into pin-point lesions. Histological examinations performed in 25 pre-pinpoint and 10 pinpoint papules and cytochemical studies showed significant differences. In the pre-pinpoint papules inflammatory infiltrates were in a great part polymorphonuclear, and the epidermis had no features characteristic of psoriasis. The earliest changes preceding the appearance of spontaneous psoriatic papules are very much like those of provoked Koebner phenomenon.

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