Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 8. Design, Synthesis, and CoMFA Studies toward the Development of Artemisinin-Based Drugs against Leishmaniasis and Malaria
- 21 August 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 46 (20) , 4244-4258
- https://doi.org/10.1021/jm030181q
Abstract
No abstract availableKeywords
This publication has 36 references indexed in Scilit:
- From Mechanistic Studies on Artemisinin Derivatives to New Modular Antimalarial DrugsAccounts of Chemical Research, 2002
- Anhydrodihydroartemisinin and Its 10-Trifluoromethyl Analogue: Access to Novel D-Ring-Contracted Artemisinin Trifluoromethyl KetonesThe Journal of Organic Chemistry, 2002
- Alkylating Capacity and Reaction Products of Antimalarial Trioxanes after Activation by a Heme ModelThe Journal of Organic Chemistry, 2002
- Possible modes of action of the artemisinin-type compoundsTrends in Parasitology, 2001
- Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with Formation of N-oxides — a chemical model for antimalarial mode of actionTetrahedron Letters, 1999
- The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug ArtemisininJournal of Biological Chemistry, 1998
- Correlation of Antimalarial Activity of Artemisinin Derivatives with Binding Affinity with Ferroprotoporphyrin IXJournal of Medicinal Chemistry, 1997
- From Qinghao, Marvelous Herb of Antiquity, to the Antimalarial Trioxane Qinghaosuand Some Remarkable New ChemistryAccounts of Chemical Research, 1997
- Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu)Antimicrobial Agents and Chemotherapy, 1993
- Qinghaosu (Artemisinin): an Antimalarial Drug from ChinaScience, 1985