In vitro activity of ciprofloxacin against methicillin-susceptible and methicillin-resistant staphylococci

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Abstract
Ciprofloxacin was found to be active against selected strains of methicillin-resistant as well as methicillin-susceptible Staphylococcus aureus and Staphylococcus epidermidis, having minimal inhibitory concentrations 4 CFU/ml. When killing kinetic studies were done with inocula of approximately 106 CFU/ml and various ciprofloxacin concentrations, the killing effect was low (10 in 6h) and regrowth of the culture was seen after 24 h in at least one Staphylococcus aureus strain. After 48 h incubation, mutants with MICs eightfold that of the parental strain had grown to a number of approximately 1010 CFU/ml.

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