Effects of phenylhydroxylamine and aminophenols in Japanese quailin vivo
- 31 December 1979
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 10 (7-8) , 495-498
- https://doi.org/10.3109/00498258009033784
Abstract
1. The effects of phenylhydroxylamine, and o- and p-aminophenol were studied in the Japanese quail. 2. Symptoms normally observed in aniline-treated birds were seen in quail after phenylhydroxylamine dosage at > 10mg/kg. Aminophenols (up to 50mg/kg) did not give these symptoms. 3. Injection of phenylhydroxylamine (50mg/kg) resulted in formation of 70% ferrihaemoglobin after 5min, following which a rapid reduction of ferrihaemoglobin was observed. 4. Phenylhydroxylamine reached highest blood concn. of 0.2μmol/ml after 5min. Phenylhydroxylamine was reduced to aniline within 5 min. 5. The effects of aniline in vivo are most probably due to O2 shortage caused by ferrihaemoglobin formation.This publication has 7 references indexed in Scilit:
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