Antenatal diagnosis of mosaic trisomy 8 confirmed in fetal tissues
- 1 October 1981
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 20 (4) , 276-280
- https://doi.org/10.1111/j.1399-0004.1981.tb01033.x
Abstract
An aneuploid karyotype with an extra submetacentric C-group chromosome was observed in all metaphase cells in 5 of 24 primary amniotic fluid cell clones and in admixture with normal cells in 2 additional clones. Trisomy 8 was demonstrated by R-banding. The parents elected to terminate the pregnancy. Successful cultures were initiated from 9 fetal tissues and aneuploid cells were observed in cultures derived from 2 separate sites in the skin.Keywords
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