Selenium Toxicity on the Early Life Stages of Zebrafish (Brachydanio rerio)

Abstract
Embryos at four stages of development and the newly hatched larvae of zebrafish (Brachydanio rerio) were exposed to selenium concentrations between 0.5 and 10 μg/ml to establish the toxic levels at the different stages. Embryo mortality was negligible at all selenium concentrations. Following hatching, mortality among the larvae sharply increased at concentrations of 3 μg/ml or greater irrespective of the embryonic stage when exposed. For most treatments, over 90% of the larvae died within 10 days of hatching. The mortality rate for larvae exposed to selenium after hatching was slightly less.

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